Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors

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Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors

Since ancient times, edible sea cucumbers have been considered a jewel of the seabed and used in Asian folk medicine for stimulation of resistance against different diseases. However, the power of this sea food has not been established on a molecular level. A particular group of triterpene glycosides was found to be characteristic metabolites of the animals, responsible for this biological acti...

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Biologically Active Triterpene Glycosides from Sea Cucumbers (holothuroidea, Echinodermata)

Sea cucumbers are characterized by their content in holothurins, triterpenoid glycosides that are responsible for the toxicity of these echinoderms. Nearly 100 holothurins isolated in the last twenty years are grouped into three main aglycone structural types: 3p-hydrox>iiolost-9(ll)-ene, 3p-hydrox5*iolost-7-ene and nonholostane based aglycones. This communication offers a general view of the s...

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Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers

Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune, and other various cells are not fully known. This review focuses on the structural characteri...

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Over five hundred and forty of seacucumbers eollected on the southern coasts of Tasmania have in the course of the present study. Seven families, 12 and 14 species are represented in the One is regarded are as new, adhaerens, TaVUtll. and Paraca.udina. Three other species have not been recorded previously from Tasmania but are known from the coast of Victoria. They are Cllcurnella Jnutans incon...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2016

ISSN: 2045-2322

DOI: 10.1038/srep39683